Continuous subcutaneous insulin infusion versus multiple daily injection regimens in children and young people at diagnosis of type 1 diabetes: pragmatic randomised controlled trial and economic evaluation.

ABSTRACT:

Objective

To compare the efficacy, safety, and cost utility of continuous subcutaneous insulin infusion (CSII) with multiple daily injection (MDI) regimens during the first year following diagnosis of type 1 diabetes in children and young people.

Design

Pragmatic, multicentre, open label, parallel group, randomised controlled trial and economic evaluation.

Setting

15 paediatric National Health Service (NHS) diabetes services in England and Wales. The study opened to recruitment in May 2011 and closed in January 2017.

Participants

Patients aged between 7 months and 15 years, with a new diagnosis of type 1 diabetes were eligible to participate. Patients who had a sibling with the disease, and those who took drug treatments or had additional diagnoses that could h

SUBMITTER: Blair JC 

PROVIDER: S-EPMC6446076 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature