Upregulation of SLC2A3 gene and prognosis in colorectal carcinoma: analysis of TCGA data.

ABSTRACT:

Background

Upregulation of SLC2A genes that encode glucose transporter (GLUT) protein is associated with poor prognosis in many cancers. In colorectal cancer, studies reporting the association between overexpression of GLUT and poor clinical outcomes were flawed by small sample sizes or subjective interpretation of immunohistochemical staining. Here, we analyzed mRNA expressions in all 14 SLC2A genes and evaluated the association with prognosis in colorectal cancer using data from the Cancer Genome Atlas (TCGA) database.

Methods

In the present study, we analyzed the expression of SLC2A genes in colorectal cancer and their association with prognosis using data obtained from the TCGA for the discovery sample, and a dataset from the Gene Expression Omnibus for the validation sa

SUBMITTER: Kim E 

PROVIDER: S-EPMC6446261 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature