Urinary angiostatin: a novel biomarker of kidney disease associated with disease severity and progression.

ABSTRACT:

Background

This study aimed to evaluate the value of urinary angiostatin levels for assessing disease severity and progression of IgA nephropathy (IgAN).

Methods

Urinary angiostatin was identified as one of the distinct proteins in samples of patients with IgAN analyzed by Raybiotech protein array, and further confirmed by enzyme-linked immunosorbent assay (ELISA).

Results

Urinary angiostatin levels were significantly higher in IgAN patients than that in healthy controls (HC) subjects and lower than in disease controls (DC) patients. The concentrations of angiostatin in urine normalized to urinary creatinine (angiostatin/Cr) were positively associated with proteinuria level. With advancing chronic kidney disease (CKD) stage, urinary angiostatin/Cr levels were graduall

SUBMITTER: Xia YY 

PROVIDER: S-EPMC6446319 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature