NMR metabolomics reveals effects of <i>Cryptosporidium</i> infections on host cell metabolome.

ABSTRACT:

Background

Cryptosporidium is an important gut microbe whose contributions towards infant and immunocompromise patient mortality rates are steadily increasing. Over the last decade, we have seen the development of various tools and methods for studying Cryptosporidium infection and its interactions with their hosts. One area that is sorely overlooked is the effect infection has on host metabolic processes.

Results

Using a ¹H nuclear magnetic resonance approach to metabolomics, we have explored the nature of the mouse gut metabolome as well as providing the first insight into the metabolome of an infected cell line. Statistical analysis and predictive modelling demonstrated new understandings of the effects of a Cryptosporidium infection, while

SUBMITTER: Miller CN 

PROVIDER: S-EPMC6446323 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature