Flagellin attenuates experimental sepsis in a macrophage-dependent manner.

ABSTRACT:

Background

Sepsis is the leading cause of death among critically ill patients, and no specific therapeutic agent is currently approved for the treatment of sepsis.

Methods

We assessed the effects of flagellin administration on survival, bacterial burden, and tissue injury after sepsis. In addition, we examined the effects on phagocytosis and bacterial killing in monocytes/macrophages.

Results

Therapeutic administration of flagellin increased bacterial clearance, decreased organ inflammation and injury, and reduced immune cell apoptosis after experimental sepsis, in a Toll-like receptor 5 (TLR5)-dependent manner. Macrophages, but not neutrophils, mediated the beneficial effects of flagellin on experimental sepsis, and flagellin induced macrophage polarization into M1 i

SUBMITTER: Yang X 

PROVIDER: S-EPMC6446324 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature