Flutamide-induced alterations in transcriptional profiling of neonatal porcine ovaries.

ABSTRACT:

Background

Androgens are involved in the regulation of ovarian development during fetal/neonatal life. Environmental chemicals displaying anti-androgenic activities may affect multiple signal transduction pathways by blocking endogenous androgen action. The aim of the current study was to examine effects of the anti-androgen flutamide on the expression of coding transcripts and long non-coding RNAs (lncRNAs) in neonatal porcine ovaries. By employing RNA-Seq technology we aimed to extend our understanding of the role of androgens in neonatal folliculogenesis and examine the impact of the anti-androgen flutamide on ovarian function.

Method

Piglets were subcutaneously injected with flutamide (50 mg/kg BW) or corn oil (controls) between postnatal days 1 and 10 (n = 3/grou

SUBMITTER: Knapczyk-Stwora K 

PROVIDER: S-EPMC6446412 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature