Molecular Antiretroviral Resistance Markers of Human Immunodeficiency Virus-1 of CRF01_AE Subtype in Bali, Indonesia.

ABSTRACT:

Background

Molecular epidemiological study of human immunodeficiency virus drugresistant (HIVDR) markers is challenging in areas where the dominant subtype is non-B.

Objective

Here we provide molecular data for HIVDR in the CRF01_AE subtype in Bali, Indonesia.

Method

Seventy patients were enrolled in this study and grouped into treatment failure and treatment naïve groups. The full-length pol gene was amplified using nested reverse transcriptase polymerase chain reaction and the product was then sequenced. The readable sequence was then subjected to Stanford HIV Drug Resistance Database genotyping.

Results

We found that clinical classification was in accordance with the presence of HIVDR markers in the pol gene. Independent of therapy history, the treatment fai

SUBMITTER: Budayanti NS 

PROVIDER: S-EPMC6446452 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature