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Emerging medical therapies for congenital adrenal hyperplasia.

ABSTRACT: Congenital adrenal hyperplasia has traditionally been treated with daily oral doses of glucocorticoids and mineralocorticoid supplements. Such therapy does not precisely replicate the adrenal cortex's circadian pattern. As a consequence, patients are intermittently overtreated or undertreated leading to growth suppression in children, excess weight gain and altered metabolism. Several new treatments are on the horizon. This article will summarize some new potential therapies as adjuncts to, or replacement for, standard therapy.

SUBMITTER: Speiser PW 

PROVIDER: S-EPMC6446492 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Emerging medical therapies for congenital adrenal hyperplasia.

Speiser Phyllis W PW  

F1000Research 20190402

Congenital adrenal hyperplasia has traditionally been treated with daily oral doses of glucocorticoids and mineralocorticoid supplements. Such therapy does not precisely replicate the adrenal cortex's circadian pattern. As a consequence, patients are intermittently overtreated or undertreated leading to growth suppression in children, excess weight gain and altered metabolism. Several new treatments are on the horizon. This article will summarize some new potential therapies as adjuncts to, or r  ...[more]

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