Nature and nurture- genes and environment- predict onset and progression of macular degeneration.

ABSTRACT: Age-related macular degeneration (AMD) is a common cause of irreversible visual loss and the disease burden is rising world-wide as the population ages. Both environmental and genetic factors contribute to the development of this disease. Among environmental factors, smoking, obesity and dietary factors including antioxidants and dietary fat intake influence onset and progression of AMD. There are also several lines of evidence that link cardiovascular, immune and inflammatory biomarkers to AMD. The genetic etiology of AMD has been and continues to be an intense and fruitful area of investigation. Genome-wide association studies have revealed numerous common variants associated with AMD and sequencing is increasing our knowledge of how rare genetic variants strongly impact disease. Evidenc

SUBMITTER: Sobrin L 

PROVIDER: S-EPMC6446565 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature