Development and validation of a haematuria cancer risk score to identify patients at risk of harbouring cancer.

ABSTRACT:

Background

A lack of consensus exists amongst national guidelines regarding who should be investigated for haematuria. Type of haematuria and age-specific thresholds are frequently used to guide referral for the investigation of haematuria.

Objectives

To develop and externally validate the haematuria cancer risk score (HCRS) to improve patient selection for the investigation of haematuria.

Methods

Development cohort comprise of 3539 prospectively recruited patients recruited at 40 UK hospitals (DETECT 1; ClinicalTrials.gov: NCT02676180) and validation cohort comprise of 656 Swiss patients. All patients were aged >18 years and referred to hospital for the evaluation of visible and nonvisible haematuria. Sensitivity and specificity of the HCRS in the validation cohort w

SUBMITTER: Tan WS 

PROVIDER: S-EPMC6446724 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature