Individual risk assessment tool for school-age asthma prediction in UK birth cohort.

ABSTRACT:

Background

Current published asthma predictive tools have moderate positive likelihood ratios (+LR) but high negative likelihood ratios (-LR) based on their recommended cut-offs, which limit their clinical usefulness.

Objective

To develop a simple clinically applicable asthma prediction tool within a population-based birth cohort.

Method

Children from the Manchester Asthma and Allergy Study (MAAS) attended follow-up at ages 3, 8 and 11 years. Data on preschool wheeze were extracted from primary-care records. Parents completed validated respiratory questionnaires. Children were skin prick tested (SPT). Asthma at 8/11 years (school-age) was defined as parentally reported (a) physician-diagnosed asthma and wheeze in the previous 12 months or (b) ≥3 wheeze attacks in the

SUBMITTER: Wang R 

PROVIDER: S-EPMC6446726 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature