K_2p 3.1 protein is expressed as a transmural gradient across the rat left ventricular free wall.

ABSTRACT:

Introduction

K_2p 3.1, also known as TASK-1, is a twin-pore acid-sensitive repolarizing K⁺ channel, responsible for a background potassium current that significantly contributes to setting the resting membrane potential of cardiac myocytes. Inhibition of I_K2p3.1 alters cardiac repolarization and is proarrhythmogenic. In this study, we have examined the expression of K_2p 3.1 and function of this channel in tissue and myocytes from across the left ventricular free wall.

Methods and results

Using fluorescence immunocytochemistry, the expression of K_2p 3.1 protein in myocytes from the subendocardial region was found to be twice (205% ± 13.5%) that found in myocytes from the subepicardial region of the left ventricle (100% ± 5

SUBMITTER: Jones SA 

PROVIDER: S-EPMC6446730 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature