Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Autism-Related Variation in Reciprocal Social Behavior: A Longitudinal Study.

ABSTRACT: Deficits in reciprocal social behavior are a characterizing feature of autism spectrum disorder (ASD). Autism-related variation in reciprocal social behavior (AVR) in the general population is continuously distributed and highly heritable-a function of additive genetic influences that overlap substantially with those which engender clinical autistic syndromes. This is the first long-term prospective study of the stability of AVR from childhood through early adulthood, conducted via serial ratings using the Social Responsiveness Scale, in a cohort-sequential study involving children with ASD, other psychiatric conditions, and their siblings (N = 602, ages = 2.5-29). AVR exhibits marked stability throughout childhood in individuals with and without ASD.

SUBMITTER: Wagner RE

PROVIDER: S-EPMC6446804 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Autism-Related Variation in Reciprocal Social Behavior: A Longitudinal Study.

Wagner Rachael E RE Zhang Yi Y Gray Teddi T Abbacchi Anna A Cormier Deporres D Todorov Alexandre A Constantino John N JN

Child development 20181022 2

Deficits in reciprocal social behavior are a characterizing feature of autism spectrum disorder (ASD). Autism-related variation in reciprocal social behavior (AVR) in the general population is continuously distributed and highly heritable-a function of additive genetic influences that overlap substantially with those which engender clinical autistic syndromes. This is the first long-term prospective study of the stability of AVR from childhood through early adulthood, conducted via serial rating ...[more]

PMID: 30346626

Similar Datasets

Genetic architecture of reciprocal social behavior in toddlers: Implications for heterogeneity in the early origins of autism spectrum disorder.

Project description: Not available

| S-EPMC8086896 | biostudies-literature

Subdimensions of social-communication behavior in autism-A replication study.

Project description: Not available

| S-EPMC10242906 | biostudies-literature

Social behavior in RASopathies and idiopathic autism.

Project description: Not available

| S-EPMC8753327 | biostudies-literature

Reciprocal processes of sensory perception and social bonding: an integrated social-sensory framework of social behavior.

Project description: Not available

| S-EPMC9744507 | biostudies-literature

CaMKI dysregulation leads to autism-related phenotypes in precise synaptic connectivity, sleep, social behavior, and aging-dependent degeneration in Drosophila

Project description:Postmortem studies reveal increased density of synapses in brains of individuals with autism spectrum disorder (ASD. These observations have led to the hypothesis that defects in synaptic pruning may contribute to ASD pathology. Synaptic pruning, also called synaptic elimination or refinement, is a neuroplastic process involving the removal of ectopic synapses formed in the initial stages of neuronal development. Studies in vertebrates and invertebrates indicate that a crucial factor regulating synaptic pruning is neuronal activity, which was first hypothesized by Nobel laureates Hubel and Wiesel in the 1960s. Studies at the vertebrate retina as well as the mammalian and Drosophila neuromuscular junction (NMJ) indicate that waves of prenatal electrical activity and calcium (Ca2+) oscillations regulate the withdrawal of off-target synaptic contacts. Ca2+ oscillations regulate Ca2+-dependent molecular factors such as kinases (e.g. CaMKII), phosphatases (Calcineurin), and Ca2+-dependent adenylyl cyclases, which in turn regulate intracellular cyclic AMP (cAMP) levels for synaptic pruning in mammalian visual neurons and at the Drosophila NMJ21. Whereas a model to explain the refinement of synaptic connections often involves mechanisms based on Hebbian-like, spike-timing correlation between synaptic partners, where asynchronous inputs are removed, alternative non-Hebbian mechanisms have also been proposed that rely on activity-dependent modulation of chemorepulsion. Although some molecular aspects underlying activity-dependent synaptic refinement have recently been elucidated what molecules link dynamic levels of neuronal activity and the refinement of synaptic contacts during development remain to be elucidated. Consistent with its contributions to advance our understanding of synaptic development, Drosophila melanogaster has emerged as a suitable genetic model system for investigating fundamental mechanisms associated with ASD.

2025-10-06 | PXD061426 | Pride

Rescue of oxytocin response and social behavior in a rodent model of autism

Project description:One of the most fundamental challenges in developing treatments for autism-spectrum disorders is the heterogeneity of the condition. More than one hundred genetic mutations confer high risk for autism, with each individual mutation accounting for only a small fraction of autism cases. Subsets of risk genes can be grouped into functionally-related pathways, most prominently synaptic proteins, translational regulation, and chromatin modifications. To possibly circumvent this genetic complexity, recent therapeutic strategies have focused on the neuropeptides oxytocin and vasopressin which regulate aspects of social behavior in mammals. However, whether genetic risk factors might predispose to autism due to modification of oxytocinergic signaling remains largely unknown. Here, we report that an autism-associated mutation in the synaptic adhesion molecule neuroligin-3 (Nlgn3) results in impaired oxytocin signaling in dopaminergic neurons and in altered social novelty responses in mice. Surprisingly, loss of Nlgn3 is accompanied by a disruption of translation homeostasis in the ventral tegmental area. Treatment of Nlgn3KO mice with a novel, highly specific, brain-penetrant inhibitor of MAP-kinase interacting kinases resets mRNA translation and restores oxytocin and social novelty responses. Thus, this work identifies an unexpected convergence between the genetic autism risk factor Nlgn3, translational regulation, and oxytocinergic signaling. Focus on such common core plasticity elements might provide a pragmatic approach to reduce the heterogeneity of autism phenotypes. Ultimately, this would allow for mechanism-based stratification of patient populations to increase the success of therapeutic interventions.

2020-04-27 | PXD018808 | Pride

Rationale, design, and methods of the Autism Centers of Excellence (ACE) network Study of Oxytocin in Autism to improve Reciprocal Social Behaviors (SOARS-B).

Project description: Not available

| S-EPMC7924986 | biostudies-literature

Maternal high-fat or low-protein diets promote autism-related behavior and altered social behavior within groups in offspring male mice.

Project description: Not available

| S-EPMC11336096 | biostudies-literature

No evidence for a reciprocal relationship between daily self-control failures and addictive behavior in a longitudinal study.

Project description: Not available

| S-EPMC11095395 | biostudies-literature

Genetic Variation in Gut Microbes as a Key Regulator of Host Social Behavior

Project description:The gut-brain axis allows gut microbes to influence host social behavior, yet the specific role of microbial genetic variation in this process and its potential transgenerational effects remains poorly understood. Using C. elegans as a model, we identified 77 E. coli strains among 3,983 mutants that markedly enhanced C. elegans aggregation behavior. Our findings reveal that mutant bacteria modulate C. elegans social behavior through distinct neurobehavioral pathways, demonstrating a synergistic regulatory mechanism between microbial genetics and host heredity. Mechanistically, ycgJ mutant bacteria were found to impact C. elegans social behavior via the mitochondrial pathway. Additionally, even F2 offspring of parent C. elegans exposed to these mutant bacteria exhibited enhanced social behavior within their populations. These insights underscore the significance of investigating microbial genetic variation in relation to host behavior, particularly for the development of genetically engineered probiotics, aimed at promoting well-being across generations.

2025-01-27 | GSE283454 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data