Antigen-presenting ILC3 regulate T cell-dependent IgA responses to colonic mucosal bacteria.

ABSTRACT: Intestinal immune homeostasis is dependent upon tightly regulated and dynamic host interactions with the commensal microbiota. Immunoglobulin A (IgA) produced by mucosal B cells dictates the composition of commensal bacteria residing within the intestine. While emerging evidence suggests the majority of IgA is produced innately and may be polyreactive, mucosal-dwelling species can also elicit IgA via T cell-dependent mechanisms. However, the mechanisms that modulate the magnitude and quality of T cell-dependent IgA responses remain incompletely understood. Here we demonstrate that group 3 innate lymphoid cells (ILC3) regulate steady state interactions between T follicular helper cells (TfH) and B cells to limit mucosal IgA responses. ILC3 used conserved migratory cues to establish residenc

SUBMITTER: Melo-Gonzalez F 

PROVIDER: S-EPMC6446868 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature