Resting-state functional connectivity and inflexibility of daily emotions in major depression.

ABSTRACT:

Background

Major Depressive Disorder (MDD) is characterized by aberrant resting-state functional connectivity (FC) in anterior cingulate regions (e.g., subgenual anterior cingulate [sgACC]) and by negative emotional functioning that is inflexible or resistant to change.

Methods

MDD (N = 33) and control (CTL; N = 31) adults completed a resting-state scan, followed by a smartphone-based Experience Sampling Methodology (ESM) protocol surveying 10 positive and negative emotions 5 times per day for 21 days. We used multilevel modeling to assess moment-to-moment emotional inflexibility (i.e., strong temporal connections between emotions). We examined group differences in whole-brain FC analysis of bilateral sgACC, and then examined associations between emotional experiences and th

SUBMITTER: Schwartz J 

PROVIDER: S-EPMC6446895 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature