Efficacy and Tolerability of High-Dose Escitalopram in Posttraumatic Stress Disorder.

ABSTRACT:

Background

Open-label trials suggest that escitalopram (up to 20 mg/d) is an effective treatment for some, but not all posttraumatic stress disorder (PTSD) patients. Higher doses of escitalopram effectively reduced major depression symptoms in patients who had not responded to regular doses. The current study examines the efficacy, tolerability, and adherence to high-dose escitalopram in PTSD.

Methods

Forty-five PTSD patients received 12 weeks of gradually increasing doses of escitalopram reaching 40 mg daily at 4 weeks. Among those, 12 participants received regular doses of antidepressants at study onset including escitalopram (n = 7). The Clinician-Administered PTSD Scale (CAPS) evaluated PTSD symptoms severity before treatment, at 3 months (upon treatment termination), an

SUBMITTER: Qi W 

PROVIDER: S-EPMC6446897 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature