Sensorimotor network hypersynchrony as an endophenotype in families with genetic generalized epilepsy: A resting-state functional magnetic resonance imaging study.

ABSTRACT: Recent evidence suggests that three specific brain networks show state-dependent levels of synchronization before, during, and after episodes of generalized spike-wave discharges (GSW) in patients with genetic generalized epilepsy (GGE). Here, we investigate whether synchronization in these networks differs between patients with GGE (n = 13), their unaffected first-degree relatives (n = 17), and healthy controls (n = 18). All subjects underwent two 10-minute simultaneous electroencephalographic-functional magnetic resonance imaging (fMRI) recordings without GSW. Whole-brain data were divided into 90 regions, and blood oxygen level-dependent (BOLD) phase synchrony in a 0.04-0.07-Hz band was estimated between all pairs of regions. Three networks were defined: (1) the network with highest syn

SUBMITTER: Tangwiriyasakul C 

PROVIDER: S-EPMC6446943 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature