Molecular subtype classification of papillary renal cell cancer using miRNA expression.

ABSTRACT:

Background

Renal papillary cell carcinoma (KIRP) is a relatively rare renal malignancy. Although KIRP subtyping about clinical relevance has been defined, there have been scarce number of studies on the molecular characteristics of KIRP subtypes.

Method

In this study, a independent samples t-test was used to identify differentially expressed (DE) miRNAs between tumor and normal samples of KIRP. Meanwhile, we performed unsupervised clustering using DE miRNA expression data to analyze molecular characteristics of KIRP. The Partitioning Around Medoids clustering approach was used to identify molecular subtypes. The cumulative distribution function (CDF), proportion of ambiguously clustered pairs (PAC), principal component analysis (PCA) and consensus heatmaps were used t

SUBMITTER: Yu C 

PROVIDER: S-EPMC6446988 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature