Clinical correlates of lung ventilation defects in asthmatic children.

ABSTRACT:

Background

Lung ventilation defects identified by using hyperpolarized 3-helium gas ((3)He) lung magnetic resonance imaging (MRI) are prevalent in asthmatic patients, but the clinical importance of ventilation defects is poorly understood.

Objectives

We sought to correlate the lung defect volume quantified by using (3)He MRI with clinical features in children with mild and severe asthma.

Methods

Thirty-one children with asthma (median age, 10 years; age range, 3-17 years) underwent detailed characterization and (3)He lung MRI. Quantification of the (3)He signal defined ventilation defect and hypoventilated, ventilated, and well-ventilated volumes.

Results

The ventilation defect to total lung volume fraction ranged from 0.1% to 11.6%. Children with ventilation d

SUBMITTER: Altes TA 

PROVIDER: S-EPMC6447058 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature