PDGF-B Is Required for Development of the Glymphatic System.

ABSTRACT: The glymphatic system is a highly polarized cerebrospinal fluid (CSF) transport system that facilitates the clearance of neurotoxic molecules through a brain-wide network of perivascular pathways. Herein we have mapped the development of the glymphatic system in mice. Perivascular CSF transport first emerges in hippocampus in newborn mice, and a mature glymphatic system is established in the cortex at 2 weeks of age. Formation of astrocytic endfeet and polarized expression of aquaporin 4 (AQP4) consistently coincided with the appearance of perivascular CSF transport. Deficiency of platelet-derived growth factor B (PDGF-B) function in the PDGF retention motif knockout mouse line Pdgfb^ret/ret suppressed the development of the glymphatic system, whose functions remained suppressed

SUBMITTER: Munk AS 

PROVIDER: S-EPMC6447074 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature