Universal genotyping reveals province-level differences in the molecular epidemiology of tuberculosis.

ABSTRACT:

Objectives

Compare the molecular epidemiology of tuberculosis (TB) between two large Canadian provinces-Ontario and British Columbia (BC)-to identify genotypic clusters within and across both provinces, allowing for an improved understanding of genotype data and providing context to more accurately identify clusters representing local transmission.

Design

We compared 24-locus Mycobacterial Interspersed Repetitive Units-Variable Number of Tandem Repeats (MIRU-VNTR) genotyping for 3,314 Ontario and 1,602 BC clinical Mycobacterium tuberculosis isolates collected from 2008 through 2014. Laboratory data for each isolate was linked to case-level records to obtain clinical and demographic data.

Results

The demographic characteristics of persons with TB varied between provinc

SUBMITTER: Guthrie JL 

PROVIDER: S-EPMC6447219 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature