Plasma Proteome Signature of Sepsis: a Functionally Connected Protein Network.

ABSTRACT: Sepsis is an extreme host response to infection that leads to loss of organ function and cardiovascular integrity. Mortality from sepsis is on the rise. Despite more than three decades of research and clinical trials, specific diagnostic and therapeutic strategies for sepsis are still absent. The use of LFQ- and TMT-based quantitative proteomics is reported here to study the plasma proteome in five mouse models of sepsis. A knowledge-based interpretation of the data reveals a protein network with extensive connectivity through documented functional or physical interactions. The individual proteins in the network all have a documented role in sepsis and are known to be extracellular. The changes in protein abundance observed in the mouse models of sepsis have for the most part the same dire

SUBMITTER: Pimienta G 

PROVIDER: S-EPMC6447370 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature