Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain.

ABSTRACT: The mammalian brain is composed of diverse, specialized cell populations. To systematically ascertain and learn from these cellular specializations, we used Drop-seq to profile RNA expression in 690,000 individual cells sampled from 9 regions of the adult mouse brain. We identified 565 transcriptionally distinct groups of cells using computational approaches developed to distinguish biological from technical signals. Cross-region analysis of these 565 cell populations revealed features of brain organization, including a gene-expression module for synthesizing axonal and presynaptic components, patterns in the co-deployment of voltage-gated ion channels, functional distinctions among the cells of the vasculature and specialization of glutamatergic neurons across cortical regions. Systematic

SUBMITTER: Saunders A 

PROVIDER: S-EPMC6447408 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature