Lp-PLA₂ activity is associated with increased risk of diabetic retinopathy: a longitudinal disease progression study.

ABSTRACT:

Aims/hypothesis

The aim of the study was to examine the association between lipoprotein-associated phospholipase A₂ (Lp-PLA₂) activity levels and incident diabetic retinopathy and change in retinopathy grade.

Methods

This was a cohort study of diabetic participants with serum collected at baseline and routinely collected diabetic retinal screening data. Participants with type 2 diabetes from the GoDARTS (Genetics of Diabetes Audit and Research in Tayside Scotland) cohort were used. This cohort is composed of individuals of white Scottish ancestry from the Tayside region of Scotland. Survival analysis accounting for informative censoring by modelling death as a competing risk was performed for the development of incident diabetic retinopathy from a disea

SUBMITTER: Siddiqui MK 

PROVIDER: S-EPMC6447502 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature