Evaluating minimal important differences and responder definitions for the asthma symptom diary in patients with moderate to severe asthma.

ABSTRACT:

Background

The Asthma Symptom Diary was developed to assess severity of symptoms in patients with moderate to severe asthma, and has evidence supporting reliability and validity. Only limited information is available on sensitivity to change and responder definitions for the Asthma Symptom Diary.

Objectives

Main study objectives were to evaluate sensitivity to change and provide responder definitions for clinically meaningful effects for the Asthma Symptom Diary.

Methods

This is a secondary analysis of Phase II clinical trial data in patients with moderate to severe asthma, Asthma Symptom Diary (ASD) was collected daily during the 24-week study. The Asthma Control Questionnaire and the Patient Global Assessment were collected at baseline, and week 12 and 24. Analysis

SUBMITTER: Globe G 

PROVIDER: S-EPMC6447631 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature