1,25-Dihydroxyvitamin D₃ Restrains CD4⁺ T Cell Priming Ability of CD11c⁺ Dendritic Cells by Upregulating Expression of CD31.

ABSTRACT: Dendritic cells (DC) are specialized sentinel cells that bridge the innate and adaptive immune response and play a crucial role in shaping the adaptive immune response. Vitamin D, a known epidemiological risk factor for the development of several autoimmune diseases, influences the development of dendritic cells. Consequently, vitamin D metabolites are frequently used in protocols to develop therapeutic dendritic cell therapies for autoimmune diseases. However, the mechanisms by which vitamin D modulates DC function remain poorly understood. We investigated the effects of vitamin D on murine CD11c⁺ bone marrow derived DC (BMDC) function by analyzing global gene expression in CD11c⁺ BMDC generated in the presence (VitD-CD11c⁺BMDC) or absence (Veh-CD11c⁺

SUBMITTER: Saul L 

PROVIDER: S-EPMC6447667 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature