GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice.

ABSTRACT: The transcription factor GATA2 regulates normal hematopoiesis, particularly in- stem cell maintenance and myeloid differentiation. Various heteroallelic GATA2 gene mutations are associated with a variety of hematological neoplasms, including myelodysplastic syndromes and leukemias. Here, we report that impaired GATA2 expression induces myelodysplastic and myeloproliferative neoplasm development in elderly animals, and this neoplasm resembles chronic myelomonocytic leukemia in humans. GATA2 hypomorphic mutant (G2^{f GN / fGN} ) mice that were generated by the germline insertion of a neocassette into the Gata2 gene locus avoided the early embryonic lethality observed in Gata2-null mice. However, adult G2^{f GN / fGN}

SUBMITTER: Harada N 

PROVIDER: S-EPMC6447832 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature