Controlling the Spatial Distribution of Solubilized Compounds within Copolymer Micelles.

ABSTRACT: The solubilization of lyophobic compounds in block copolymer micelles has been extensively investigated but remains only partially understood. There is a need to understand the fundamental parameters that determine the spatial distribution of the solubilized compounds within the micelles. Controlling this feature is a key aspect in the design of drug delivery systems with tailored release properties. Using Scheutjens-Fleer self-consistent field (SF-SCF) computations, we found that solubilization is regulated by a complex interplay between enthalpic and entropic contributions and that the spatial distribution can be controlled by the concentration and solubility of the guest compound in the dispersion medium. Upon solubilization, a characteristic change in size and mass of the micelles is p

SUBMITTER: Ianiro A 

PROVIDER: S-EPMC6448116 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature