Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users.

ABSTRACT:

Objective

To identify genetic variants that influence steady-state etonogestrel concentrations among contraceptive implant users.

Methods

We enrolled healthy, reproductive-age women in our pharmacogenomic study using etonogestrel implants for 12-36 months without concomitant use of hepatic enzyme inducers or inhibitors. We collected participant characteristics, measured serum etonogestrel concentrations, and genotyped each participant for 120 single nucleotide variants in 14 genes encoding proteins involved in steroid hormone (ie, estrogens, progestins) metabolism, regulation, or function. We performed generalized linear modeling to identify genetic variants associated with steady-state etonogestrel concentrations.

Results

We enrolled 350 women, who had a median serum

SUBMITTER: Lazorwitz A 

PROVIDER: S-EPMC6448146 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature