A novel human 3D lung microtissue model for nanoparticle-induced cell-matrix alterations.

ABSTRACT:

Background

Multi-walled carbon nanotubes (MWCNT) have been shown to elicit the release of inflammatory and pro-fibrotic mediators, as well as histopathological changes in lungs of exposed animals. Current standards for testing MWCNTs and other nanoparticles (NPs) rely on low-throughput in vivo studies to assess acute and chronic toxicity and potential hazard to humans. Several alternative testing approaches utilizing two-dimensional (2D) in vitro assays to screen engineered NPs have reported conflicting results between in vitro and in vivo assays. Compared to conventional 2D in vitro or in vivo animal model systems, three-dimensional (3D) in vitro platforms have been shown to more closely recapitulate human physiology, providing a relevant, more efficient strategy for evaluating ac

SUBMITTER: Kabadi PK 

PROVIDER: S-EPMC6448215 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature