Short telomeres correlate with a strong induction of cellular senescence in human dental follicle cells.

ABSTRACT:

Background

Dental follicle cells (DFCs) are dental stem cells and interesting options for regenerative therapies in dentistry. However, DFCs acquire replicative senescence in long-term cultures, but little is known about molecular processes. In previous studies, we observed that DFC cell lines become senescent at different rates. We hypothesized that short telomere length and increased DNA damage with genomic instability correlate with the accelerated induction of cellular senescence.

Results

For this study we compared DFC cell lines that became senescent at different rates (DFC_F: strong senescent phenotype; DFC_S: weak senescent phenotype). The telomeres of DFC_F were shorter than those of the telomeres of DFC_S prior senescence. Interestingly, telomere lengths of both cel

SUBMITTER: Morsczeck C 

PROVIDER: S-EPMC6448245 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature