Nodal induces apoptosis and inhibits proliferation in ovarian endometriosis-clear cell carcinoma lesions.

ABSTRACT:

Background

Expression of Nodal, a member of the TGF-β superfamily, is commonly absent in differentiated tissues, while its re-expression occurs in a variety of human malignancy. However, little is known about its involvement in ovarian tumorigenesis. Herein, we focused on the functional roles of Nodal in ovarian endometriosis-carcinoma lesions.

Methods

Regulation and function of Nodal and its associated molecules, including Smad2, GSK-3β, and several cell kinetics-related molecules, were assessed using clinical samples consisting of 108 ovarian carcinomas and 33 endometriotic lesions, as well as ES-2 (ovarian clear cell carcinoma; OCCCa) and Ishikawa (endometrial carcinoma) cell lines.

Results

Nodal expression was significantly higher in endometriosis and OCCCa lesion

SUBMITTER: Miura R 

PROVIDER: S-EPMC6448249 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature