Porphyria cutanea tarda increases risk of hepatocellular carcinoma and premature death: a nationwide cohort study.

ABSTRACT:

Background

Porphyria cutanea tarda (PCT) is a skin disorder originating from a deficit of the liver enzyme uroporphyrinogen decarboxylase. PCT may be a risk factor for hepatocellular carcinoma (HCC) and other cancers, but the evidence is unclear. We aimed to investigate cancer and premature mortality risk in persons with PCT.

Methods

The cohort study consisted of all Norwegian residents from 18 years between 2000 and 2016 (n = 5.4 million). 612 persons with PCT, and all cancer diagnoses and causes of death were identified through record linkage between national registries. Hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) were adjusted for age, sex, education and calendar years. We additionally compared persons with PCT to persons with a history of chronic

SUBMITTER: Baravelli CM 

PROVIDER: S-EPMC6448269 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature