MicroRNA-663 facilitates the growth, migration and invasion of ovarian cancer cell by inhibiting TUSC2.

ABSTRACT:

Background

MicroRNAs (miRNAs) have emerged as the critical modulators of the tumorigenesis and tumor progression.

Methods

The levels of miR-663 in ovarian cancer cell lines and clinical tissues were detected using qRT-PCR assays. The Transwell invasion and wound healing assay were conducted to assess the roles of miR-663 in the migration and invasion of ovarian cancer cell in vitro. Rescue assays were carried out to confirm the contribution of tumor suppressor candidate 2 (TUSC2) in the aggressiveness of cancer cell which was regulated by miR-663.

Results

The levels of miR-663 were up-regulated in ovarian cancer tissues in comparison with the corresponding normal tissues. Up-regulation of miR-663 increased the proliferation, colony formation, migration and invasion of

SUBMITTER: Xie HH 

PROVIDER: S-EPMC6448305 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature