Solute carrier family 9, subfamily A, member 3 (SLC9A3)/sodium-hydrogen exchanger member 3 (NHE3) dysregulation and dilated intercellular spaces in patients with eosinophilic esophagitis.

ABSTRACT:

Background

Eosinophilic esophagitis (EoE) is characterized by histopathologic modifications of esophageal tissue, including eosinophil-rich inflammation, basal zone hyperplasia, and dilated intercellular spaces (DIS). The underlying molecular processes that drive the histopathologic features of EoE remain largely unexplored.

Objective

We sought to investigate the involvement of solute carrier family 9, subfamily A, member 3 (SLC9A3) in esophageal epithelial intracellular pH (pH_i) and DIS formation and the histopathologic features of EoE.

Methods

We examined expression of esophageal epithelial gene networks associated with regulation of pH_i in the EoE transcriptome of primary esophageal epithelial cells and an in vitro esophageal epithelial 3-dime

SUBMITTER: Zeng C 

PROVIDER: S-EPMC6448407 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature