Risk factors for suicidality in Huntington disease: An analysis of the 2CARE clinical trial.

ABSTRACT:

Objective

Most suicidality literature in Huntington disease (HD) is based on natural history studies or retrospective reviews, but reports on risk factors from clinical trials are limited.

Methods

We analyzed 609 participants from 2CARE, a randomized, double-blind, placebo-controlled clinical trial with up to 5 years of follow-up, for risk factors related to suicidality. The primary outcome variable was the time from randomization until the first occurrence of either suicidal ideation or attempt. We also considered time from randomization until the first suicide attempt as a secondary outcome variable.

Results

Depression, anxiety, bipolar disorder, antidepressant or anxiolytic use, and prior suicide attempt at baseline were associated with time to ideation or attempt.

SUBMITTER: McGarry A 

PROVIDER: S-EPMC6448454 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature