Evidence of Local Concentration of α-Particles from ²¹¹At-Labeled Antibodies in Liver Metastasis Tissue.

ABSTRACT: We investigated the local concentration of α-particles from ²¹¹At-labeled trastuzumab antibodies against human epidermal growth factor receptor type 2 antigens in liver metastasis tissue of mice. Methods: Mice carrying metastatic cancer in their liver were injected with ²¹¹At-agent. After 12 h, the liver was removed and sliced, and 2 tissue samples of liver tissues without lesions and one containing metastatic lesions were mounted on the CR-39 plastic nuclear track detector. Microscope images of the tissues on the CR-39 were acquired. After irradiation for 31 h, the tissues were removed from the CR-39. A microscope image of α-particle tracks on the CR-39 was acquired after chemical etching. The positions of each tissue sample and the emitted α-particle tracks w

SUBMITTER: Kodaira S 

PROVIDER: S-EPMC6448461 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature