Assessing Amyloid Pathology in Cognitively Normal Subjects Using ¹⁸F-Flutemetamol PET: Comparing Visual Reads and Quantitative Methods.

ABSTRACT: Our objective was to determine the optimal approach for assessing amyloid disease in a cognitively normal elderly population. Methods: Dynamic ¹⁸F-flutemetamol PET scans were acquired using a coffee-break protocol (a 0- to 30-min scan and a 90- to 110-min scan) on 190 cognitively normal elderly individuals (mean age, 70.4 y; 60% female). Parametric images were generated from SUV ratio (SUVr) and nondisplaceable binding potential (BP_ND) methods, with cerebellar gray matter as a reference region, and were visually assessed by 3 trained readers. Interreader agreement was calculated using κ-statistics, and semiquantitative values were obtained. Global cutoffs were calculated for both SUVr and BP_ND using a receiver-operating-characteristic analysis and th

SUBMITTER: Collij LE 

PROVIDER: S-EPMC6448465 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature