Microemulsions vs chitosan derivative-coated microemulsions for dermal delivery of 8-methoxypsoralen.

ABSTRACT:

Background

8-methoxypsoralen (8-MOP) is one of the most commonly utilized drugs in psoralen-ultraviolet A therapy for treatment of vitiligo. However, poor skin retention and systemic side effects limit the clinical application of 8-MOP.

Methods

Microemulsions (MEs) and chitosan derivative-coated 8-MOP MEs were developed and compared for dermal delivery of 8-MOP. Ex vivo skin retention/permeation study was performed to select the ME formulation with the highest retention:permeation ratio. Four different chitosan-coated MEs were prepared and compared with the ME formulation for their ability to distribute 8-MOP in the skin.

Results

Among various ME formulations developed, a formulation containing 2.9% ethyl oleate, 17.2% Cromophor EL35, 8.6% ethanol and 71.3% water show

SUBMITTER: Wu JY 

PROVIDER: S-EPMC6448538 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature