Mucus-penetrating phage-displayed peptides for improved transport across a mucus-like model.

ABSTRACT: The objective of this work is to use phage display libraries as a screening tool to identify peptides that facilitate transport across the mucus barrier. Mucus is a complex selective barrier to particles and molecules, limiting penetration to the epithelial surface of mucosal tissues. In mucus-associated diseases such as cystic fibrosis (CF), mucus has increased viscoelasticity and a higher concentration of covalent and non-covalent physical entanglements compared to healthy tissues, which greatly hinders permeability and transport of drugs and particles across the mucosae for therapeutic delivery. Treatment of CF lung diseases and associated infections must overcome this abnormal mucosal barrier. Critical bottlenecks hindering effective drug penetration remain and while recent studies hav

SUBMITTER: Leal J 

PROVIDER: S-EPMC6448585 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature