Plasma metabolites associated with type 2 diabetes in a Swedish population: a case-control study nested in a prospective cohort.

ABSTRACT:

Aims/hypothesis

The aims of the present work were to identify plasma metabolites that predict future type 2 diabetes, to investigate the changes in identified metabolites among individuals who later did or did not develop type 2 diabetes over time, and to assess the extent to which inclusion of predictive metabolites could improve risk prediction.

Methods

We established a nested case-control study within the Swedish prospective population-based Västerbotten Intervention Programme cohort. Using untargeted liquid chromatography-MS metabolomics, we analysed plasma samples from 503 case-control pairs at baseline (a median time of 7 years prior to diagnosis) and samples from a subset of 187 case-control pairs at 10 years of follow-up. Discriminative metabolites between cases and

SUBMITTER: Shi L 

PROVIDER: S-EPMC6448991 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature