Hepatic R2* is more strongly associated with proton density fat fraction than histologic liver iron scores in patients with nonalcoholic fatty liver disease.

ABSTRACT:

Background

The liver R2* value is widely used as a measure of liver iron but may be confounded by the presence of hepatic steatosis and other covariates.

Purpose

To identify the most influential covariates for liver R2* values in patients with nonalcoholic fatty liver disease (NAFLD).

Study type

Retrospective analysis of prospectively acquired data.

Population

Baseline data from 204 subjects enrolled in NAFLD/NASH (nonalcoholic steatohepatitis) treatment trials.

Field strength

1.5T and 3T; chemical-shift encoded multiecho gradient echo.

Assessment

Correlation between liver proton density fat fraction and R2*; assessment for demographic, metabolic, laboratory, MRI-derived, and histological covariates of liver R2*.

Statistical tests

Pearson's

SUBMITTER: Bashir MR 

PROVIDER: S-EPMC6449180 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature