Ontology highlight
ABSTRACT:
SUBMITTER: Simon M
PROVIDER: S-EPMC6449196 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Cell metabolism 20190307 4
Mice deficient for SIRT6 exhibit a severely shortened lifespan, growth retardation, and highly elevated LINE1 (L1) activity. Here we report that SIRT6-deficient cells and tissues accumulate abundant cytoplasmic L1 cDNA, which triggers strong type I interferon response via activation of cGAS. Remarkably, nucleoside reverse-transcriptase inhibitors (NRTIs), which inhibit L1 retrotransposition, significantly improved health and lifespan of SIRT6 knockout mice and completely rescued type I interfero ...[more]