Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury.

ABSTRACT:

Objectives

Traumatic brain injury triggers multiple cell death pathways, possibly including ferroptosis-a recently described cell death pathway that results from accumulation of 15-lipoxygenase-mediated lipid oxidation products, specifically oxidized phosphatidylethanolamine containing arachidonic or adrenic acid. This study aimed to investigate whether ferroptosis contributed to the pathogenesis of in vitro and in vivo traumatic brain injury, and whether inhibition of 15-lipoxygenase provided neuroprotection.

Design

Cell culture study and randomized controlled animal study.

Setting

University research laboratory.

Subjects

HT22 neuronal cell line and adult male C57BL/6 mice.

Interventions

HT22 cells were subjected to pharmacologic induction of ferroptosi

SUBMITTER: Kenny EM 

PROVIDER: S-EPMC6449247 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature