Ontology highlight
ABSTRACT:
SUBMITTER: Li J
PROVIDER: S-EPMC6449404 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Nature communications 20190404 1
CTCF plays key roles in gene regulation, chromatin insulation, imprinting, X chromosome inactivation and organizing the higher-order chromatin architecture of mammalian genomes. Previous studies have mainly focused on the roles of the canonical CTCF isoform. Here, we explore the functions of an alternatively spliced human CTCF isoform in which exons 3 and 4 are skipped, producing a shorter isoform (CTCF-s). Functionally, we find that CTCF-s competes with the genome binding of canonical CTCF and ...[more]