Spectroscopic and viscometric determination of DNA-binding modes of some bioactive dibenzodioxins and phenazines.

ABSTRACT: Push-pull dibenzodioxins and phenazines having 'anthracene-like' planar structures and good charge transfer character had been previously synthesised in our laboratory. The dibenzodioxins had earlier proven their anti-proliferative nature against HeLa tumor cell lines. Since phenazines are structural analogues of the former, these molecules were evaluated in course of the current study for their cytotoxic action against HeLa cell lines and they exhibited strong anti-tumor activity. This behavior could be related to their good DNA binding property. The DNA binding modes of molecules 1-4 (Fig. 1) were evaluated using various experimental techniques and they interacted with DNA in a non-covalently by both intercalative as well as groove binding mechanisms. Molecule 1 foll

SUBMITTER: Phadte AA 

PROVIDER: S-EPMC6449707 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature