CDRgator: An Integrative Navigator of Cancer Drug Resistance Gene Signatures.

ABSTRACT: Understanding the mechanisms of cancer drug resistance is a critical challenge in cancer therapy. For many cancer drugs, various resistance mechanisms have been identified such as target alteration, alternative signaling pathways, epithelial-mesenchymal transition, and epigenetic modulation. Resistance may arise via multiple mechanisms even for a single drug, making it necessary to investigate multiple independent models for comprehensive understanding and therapeutic application. In particular, we hypothesize that different resistance processes result in distinct gene expression changes. Here, we present a web-based database, CDRgator (Cancer Drug Resistance navigator) for comparative analysis of gene expression signatures of cancer drug resistance. Resistance signatures were extracted fr

SUBMITTER: Jang SK 

PROVIDER: S-EPMC6449719 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature