Differential methylation values in differential methylation analysis.

ABSTRACT:

Motivation

Both β-value and M-value have been used as metrics to measure methylation levels. The M-value is more statistically valid for the differential analysis of methylation levels. However, the β-value is much more biologically interpretable and needs to be reported when M-value method is used for conducting differential methylation analysis. There is an urgent need to know how to interpret the degree of differential methylation from the M-value. In M-value linear regression model, differential methylation M-value ΔM can be easily obtained from the coefficient estimate, but it is not straightforward to get the differential methylation β-value, Δβ since it cannot be obtained from the coefficient alone.

Results

To fill the gap, we have built a bridge to connect the statis

SUBMITTER: Xie C 

PROVIDER: S-EPMC6449748 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature