Altered frontal white matter asymmetry and its implications for cognition in schizophrenia: A tractography study.

ABSTRACT:

Background

White matter (WM) alterations are well documented in schizophrenia. Abnormalities in interhemispheric fibers appear to account for altered WM asymmetry in the illness. However, the regional specificity (e.g., frontal versus occipital) of these alterations and their potential contribution to cognitive dysfunction in schizophrenia remain unknown.

Methods

Forty one patients with schizophrenia and 21 healthy controls (HC) underwent diffusion-weighted imaging on a 3 Tesla MRI machine. Tract-based spatial statistic (FSL) was used to assess whole brain differences in WM. Probabilistic tractography was performed in order to separately measure frontal and occipital WM tracts. Participants also completed tests of verbal memory and processing speed. Repeated measures analyse

SUBMITTER: Gomez-Gastiasoro A 

PROVIDER: S-EPMC6449782 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature