Functional evolution of two subtly different (similar) folds.

ABSTRACT: BACKGROUND:The function of proteins is a direct consequence of their three-dimensional structure. The structural classification of proteins describes the ways of folding patterns all proteins could adopt. Although, the protein folds were described in many ways the functional properties of individual folds were not studied. RESULTS:We have analyzed two beta-barrel folds generally adopted by small proteins to be looking similar but have different topology. On the basis of the topology they could be divided into two different folds named SH3-fold and OB-fold. There was no sequence homology between any of the proteins considered. The sequence diversity and loop variability was found to be important for various binding functions. CONCLUSIONS:The function of Oligonucleotide/oligosaccharide-bindi

SUBMITTER: Agrawal V 

PROVIDER: S-EPMC64500 | biostudies-literature | 2001

REPOSITORIES: biostudies-literature